Ibogaine can also successfully interrupt stimulant addictions, mainly through its ability to modulate the release of dopamine in the brain and "reset" countless other neurochemical pathways, many of which are still not yet understood. Withdrawals from cocaine and crack are usually not physical; they are generally "mental" in the sense of the addict experiencing intense anxiety, sleeplessness, and constant cravings for their drug. Because stimulant dependence is mainly connected to the release of the neurotransmitter dopamine, ibogaine interrupts these "mental" withdrawal symptoms through its action on the dopamine pathways, changing the way dopamine is released.
Methamphetamine, when used heavily, can cause a physical withdrawal syndrome